Through friends buy maxaquin At LMB, Milstein was already working on this, so they decided to collaborate. However, their approach was frustratingly slow. This prompted Neuberger to search for a much faster somatic hypermutating experimental system, and with a PhD student, Julian Sale, he made a breakthrough by discovering that certain B lymphocyte cell lines do indeed possess this property. The next step was to identify the hypermutator gene, but the race for this was cut short in 2000 by the identification by Tasuku Honjo of Kyoto University, Japan, of a gene called activation induced deaminase – or AID. Genetic inactivation of AID in man or mouse abolished hypermutation.